Premier League Champions Manchester City will travel to Arsenal on the weekend of 11-12 August for their opening match of the 2018-19 season.
Tottenham visit Newcastle first, then play Fulham at Wembley while their new £850m stadium is completed.
Manchester United host Leicester City, Liverpool entertain West Ham, and Championship winners Wolverhampton Wanderers welcome Everton to Molineux.
Promoted Fulham host Crystal Palace, while Cardiff visit Bournemouth.
The three other fixtures on the opening weekend see Chelsea travel to Huddersfield, Southampton host Burnley, and Watford take on Brighton at Vicarage Road.
Arsenal go into the season under new management after Unai Emery succeeded Arsene Wenger, who has left after 22 years in charge.
And the Spaniard has been given a testing opening to life in the Premier League.
After the opening-weekend game at Etihad Stadium, the Gunners travel to fellow top-six contenders Chelsea.
Emery also has a tough start to December, with a home north London derby against Tottenham on 1 December followed by a trip to Manchester United.
Premier League opening weekend fixtures
Arsenal v Manchester City
Bournemouth v Cardiff City
Fulham v Crystal Palace
Huddersfield Town v Chelsea
Liverpool v West Ham United
Manchester United v Leicester City
Newcastle United v Tottenham Hotspur
Southampton v Burnley
Watford v Brighton
Wolverhampton Wanderers v Everton